If you are running ESXi 6.5 with IPv6 disabled, you are at risk of a host failure with PSOD.
Everything you need to know about PSOD.
The Runecast vRO plugin version 1.0.3 comes with built-in workflows for enforcing security configuration for VMs, Hosts and DVPortgroups.
Be aware that using either E1000 or E1000e on an ESXi 5.x host can pose a serious danger, depending on your host patch level.
To sum up, if you have ESXi hosts running 6.0 U2 with LRO enabled and hosting VMs with hardware version 11, you should take quick actions to avoid PSOD.
This article's purpose is to shed more light on the benefits of using the VMware KBs (Knowledge Base articles) in a proactive way - aimed at improving system resilience and performance. This can be achieved by minimizing the likelihood of service-impacting incidents or events from occurring and/or to mitigate the impact if they do occur.